I-PRP Tube eneGel
Inkcazelo emfutshane:
Okucacileyo.Okuzenzekelayoiplasma eneplatelet eninzi(i-PRP) i-gel isetyenziselwa ngakumbi kunyango lweentlobo ezahlukeneyo ze-soft and bony tissue defect, ezifana nokukhawulezisa ukubunjwa kwamathambo kunye nokulawulwa kwezilonda ezingapheliyo ezingaphiliyo.
Zonke iiseli zegazi ziphuma kwi-pluripotent stem cell eqhelekileyo, eyahlula kwiiseli ezahlukeneyo.Nganye kolu luhlu lweeseli luqulethe izandulela ezinokwahlula kwaye ziqole.
Iiplatelets, ezikwabizwa ngokuba zii-thrombocytes, zikhula kumongo wethambo.IiPlatelets zi-nucleated, iiseli ze-discoid ezinobukhulu obahlukeneyo kunye nobuninzi obumalunga ne-2 μm ububanzi, ubuninzi obuncinane bazo zonke iiseli zegazi.Ubalo lomzimba lweeplatelet ezijikeleza kumjelo wegazi lusuka kwi-150,000 ukuya kwi-400,000 yeeplatelet nge-μL.
IiPlatelets ziqulethe iigranules ezininzi eziyimfihlo ezibalulekileyo ekusebenzeni kweplatelet.Kukho iintlobo ezi-3 zeegranules: iigranules ezishinyeneyo, ii-o-granules, kunye ne-lysosomes.Kwiplatelet nganye kukho malunga ne-50-80 granules, eyona nto ininzi kakhulu kwiindidi ezi-3 zeegranules.
IiPlatelets zinoxanduva oluphambili lwenkqubo yokudibanisa.Umsebenzi ophambili kukuba negalelo kwi-homeostasis trough ye-3 iinkqubo: ukunamathela, ukuvuselela, kunye nokudibanisa.Ngexesha le-vascular lesion, iiplatelet ziyasebenza, kwaye i-granules yazo ikhupha izinto ezikhuthaza ukudibanisa.
Iiplatelet zazicingelwa ukuba zinomsebenzi we-hemostatic kuphela, nangona kwiminyaka yamuva nje, uphando lwezenzululwazi kunye nobuchwepheshe bunikeze imbono entsha kwiiplatelet kunye nemisebenzi yazo.Izifundo zibonisa ukuba iiplatelet ziqulethe ubuninzi be-GF kunye ne-cytokines ezinokuchaphazela ukuvuvukala, i-angiogenesis, i-stem cell migration, kunye nokwanda kweeseli.
I-PRP ngumthombo wendalo wokubonisa iamolekyu, kwaye emva kokusebenza kweeplatelet kwi-PRP, i-P-granules i-granulated kwaye ikhulule i-GF kunye ne-cytokines eya kuguqula i-microenvironment yeselula nganye.Ezinye zezona zinto zibalulekileyo ze-GF ezikhutshwe ngamaplatelets kwi-PRP ziquka i-vascular endothelial GF, i-fibroblast GF (FGF), i-GF ephuma kwiplatelet, i-epidermal GF, i-hepatocyte GF, i-insulin-efana ne-GF 1, i-2 (IGF-1, IGF-2), matrix metalloproteinase 2, 9, kunye ne-interleukin 8.
