HA PRP Collection Tube
Inkcazelo emfutshane:
I-HA yi-hyaluronic acid, eyaziwa ngokuba yi-hyaluronic acid, igama elipheleleyo lesiNgesi: i-hyaluronic acid.I-asidi ye-Hyaluronic yeyosapho lwe-glycosaminoglycan, oluqulunqwe ngeeyunithi eziphindaphindiweyo ze-disaccharide.Iya kufunxwa kwaye iboliswe ngumzimba womntu.Ixesha layo lesenzo lide kunelo le-collagen.Inokwandisa ixesha lesenzo ngokudibanisa, kwaye umphumo unokuhlala kwiinyanga ezi-6-18.
Utshintsho oluphambili lwe-pathophysiological ye-knee osteoarthritis yilahleko ye-cartilage, i-subchondral bone reconstruction, i-osteophyte formation kunye ne-synovial inflammatory reaction.Ukubonakaliswa kwangaphambili kweklinikhi kukuvuvukala, intlungu kunye nokuqina kwamalungu kunye nezicubu ezijikelezayo.Ngenkqubela phambili yesi sifo, ngokuthe ngcembe ikhokelela ekungasebenzi kakuhle kwamalungu kwaye ichaphazela kakhulu umgangatho wobomi.Ngokutsho kolu phando, izinga lokukhubazeka kwe-osteoarthritis emhlabeni jikelele laliyi-2.2% kwi-2010, kwaye inani labantu abakhubazekileyo kulo nyaka lidlula i-1.7 yezigidi, eziye zazisa umonakalo omkhulu kuluntu, iintsapho kunye nabantu ngabanye.I-HA yi-molecular polysaccharide biomaterial eyenziwe ngokutshintshana ngokuphindaphindiweyo kwe-n-acetylglucuronic acid.Iyona nxalenye ephambili ye-synovial fluid edibeneyo kunye nenye yamacandelo e-cartilage matrix.Idlala indima kwisondlo kunye nokukhuselwa kwamalungu.I-HA kunyango lwe-osteoarthritis ibonakaliswe ngokweklinikhi ukuba inefuthe elithile ekunciphiseni iimpawu zentlungu yamadolo kunye nokuphucula ukuhamba kwamadolo.Nangona kunjalo, ngenxa yokungabikho kobungqina obusekelwe kwinkxaso, ngokukodwa ukungaqiniseki kwexesha elide, izikhokelo ze-AAOS zakutshanje zokuxilongwa kunye nokunyangwa kwe-knee osteoarthritis ayicebisi ukusetyenziswa kwe-hyaluronic acid, kwaye inqanaba lokuncoma likhuthazwa kakhulu.I-Triamcinolone i-acetonide, njenge-glucocorticoid yokwenziwa kwexesha elide, inomphumo onamandla kunye nesigxina esichasayo.
Indlela yayo kukuthintela i-phagocytosis kunye nokucutshungulwa kwee-antigens ngamacrophages;Ukuzinzisa i-lysosomal membrane kunye nokunciphisa ukukhululwa kwe-hydrolase kwi-lysosome;Ukuthintela ukufuduka kwe-leukocytes kunye ne-macrophages ngaphandle kwemithambo yegazi kunye nokunciphisa ukusabela okuvuthayo.Olu pho nonongo lubonisa ukuba umphumo we-intra-articular injection ye-triamcinolone acetonide ilungile kwinyanga enye emva konyango, kodwa ngexesha lokuthatha umhlalaphantsi, ngakumbi emva kweenyanga ze-6 zonyango, umphumo ungaphantsi kakhulu kwamanye amaqela amabini.I-Mcalindon kunye nezinye izifundo zibonise ukuba izigulane ezinempawu ezine-knee osteoarthritis, inaliti ye-intraarticular ye-triamcinolone acetonide ibangele ukulahleka okukhulu kwe-cartilage umthamo kwaye akukho mmahluko omkhulu kwiintlungu zedolo xa kuthelekiswa ne-saline eqhelekileyo.
Ezi zifundo zingentla aziluxhasi olu nyango kwizigulane ezineempawu ezine-knee osteoarthritis.Abanye abaphandi basebenzise i-triamcinolone acetonide kunye ne-sodium hyaluronate intra-articular injection ukuze baphathe i-knee osteoarthritis, kunye nokusebenza kwayo kwexesha elifutshane kunye nexesha elide lingcono kune-hyaluronic acid yodwa.Njengonyango olutsha, i-PRP inokufumaneka kwigazi le-autologous peripheral blood, ngaphandle kokulahlwa komzimba, kwaye iqulethe ukugxila okuphezulu kwezinto zokukhula.Izinto zokukhula ziye zabonakaliswa ukukhuthaza ukwanda kwe-chondrocyte kunye ne-extracellular matrix synthesis.Ngaphezu koko, uphando olutshanje luye lwabonisa ukuba i-PRP inokuthintela ukuvutha kwamahhala kwebhaktheriya ye-synovium kwinqanaba elithile ngelixa ikhuthaza ukuvuselelwa kwe-chondrocyte.Uvavanyo oluninzi lwezilwanyana kunye nezifundo zeklinikhi zibonisa ukusebenza kakuhle kwayo.Olu pho nonongo lubonisa ukuba inqaku le-WOMAC le-PRP kwi-1 kunye neenyanga ze-3 emva kokuba unyango lulingana ne-hyaluronic acid, kunye nenqaku le-WOMAC le-PRP kwiinyanga ze-6 emva kokuba unyango lungcono kunamanye amaqela amabini, ebonisa ukuba une isiphumo esihle sokunyanga esiphakathi kunye nexesha elide.Nangona kunjalo, ngenxa yokunqongophala kophando lwexesha elide lokulandela ikliniki yeesampuli ezinkulu kunye nokungabikho kwenkxaso ngokuthe ngqo kwi-biology ye-molecular okanye i-MRI imaging, uphando olongezelelweyo kunye neengxoxo zisafuneka.
