I-GFs kunye ne-bioactive molecules ekhoyo kwi-PRP ikhuthaza izenzo eziphambili ze-4 kwindawo yendawo yolawulo, njengokunyuka, ukufuduka, ukuhlukana kweeseli, kunye ne-angiogenesis.Ii-cytokines ezahlukeneyo kunye ne-GFs zibandakanyeka kulawulo lwe-morphogenesis yeenwele kunye nokukhula kweenwele zomjikelezo.
I-dermal papilla (DP) iiseli zivelisa i-GFs ezifana ne-IGF-1, i-FGF-7, i-hepatocyte factor factor, kunye ne-vascular endothelial growth factor ejongene nokugcina i-follicle yeenwele kwisigaba se-anagen somjikelezo weenwele.Ngoko ke, into ekujoliswe kuyo iya kuba kukulawula ezi GFs ngaphakathi kweeseli ze-DP, ezongeza isigaba se-anagen.
Ngokophononongo olwenziwa ngu-Akiyama et al, ukukhula kwe-epidermal kunye nokuguqula ukukhula kubandakanyeka ekulawuleni ukukhula kunye nokuhlukana kweeseli ze-bulge, kunye ne-platelet-derived factor growth ingaba nemisebenzi ehambelanayo ekusebenzisaneni phakathi kwe-bulge kunye nezicubu ezinxulumene nazo, ukuqala nge-follicle morphogenesis.
Ngaphandle kwe-GFs, isigaba se-anagen siphinde sisebenze yi-Wnt / β-catenin / T-cell factor lymphoid enhancer.Kwiiseli ze-DP, ukusetyenziswa kwe-Wnt kuya kukhokelela ekuqokeleleni kwe-β-catenin, leyo, ngokudibanisa ne-T-cell factor lymphoid enhancer, iphinda isebenze njenge-co-activator yokubhalwa kunye nokukhuthaza ukwanda, ukusinda, kunye ne-angiogenesis.Iiseli ze-DP ziqala ukwahlula kwaye ngenxa yoko ukuguquka ukusuka kwi-telogen ukuya kwisigaba se-anagen.Ukubonakaliswa kwe-β-Catenin kubalulekile ekuphuhliseni i-follicle yabantu kunye nomjikelezo wokukhula kweenwele.
Enye indlela evezwe kwi-DP kukusebenza kwe-extracellular signal-regulated kinase (ERK) kunye ne-protein kinase B (Akt) isibonakaliso esikhuthaza ukusinda kweeseli kunye nokukhusela i-apoptosis.
Indlela echanekileyo apho i-PRP ikhuthaza ukukhula kweenwele ayiqondwa ngokupheleleyo.Ukuphonononga iindlela ezinokuthi zibandakanyeke, u-Li et al, wenza uphando oluyilwe kakuhle ukuphanda imiphumo ye-PRP ekukhuleni kweenwele usebenzisa i-in vitro kunye ne-vivo model.Kwimodeli ye-in vitro, i-PRP esebenzayo isetyenziswe kwiiseli ze-DP zomntu ezifunyenwe kwisikhumba esiqhelekileyo somntu.Iziphumo zibonise ukuba i-PRP yandisa ukwanda kweeseli ze-DP zabantu ngokuvula i-ERK kunye ne-Akt yokubonisa, okukhokelela kwimiphumo ye-antiapoptotic.I-PRP iphinde yandise umsebenzi we-β-catenin kunye ne-FGF-7 inkcazo kwiiseli ze-DP.Ngokuphathelele kwimodeli ye-vivo, iigundane ezifakwe kwi-PRP esebenzayo zibonise utshintsho olukhawulezayo lwe-telogen-to-anagen xa kuthelekiswa neqela lolawulo.
Kungekudala, i-Gupta kunye noCarviel baphinde bacebise indlela yokwenza i-PRP kwi-follicles yabantu equka "ukukhutshwa kwe-Wnt / β-catenin, i-ERK, kunye ne-Akt yokubonisa iindlela ezikhuthaza ukusinda kweeseli, ukwanda, kunye nokwahlula."
Emva kokuba i-GF ibophelela kunye ne-receptor yayo ye-GF, ukubonakaliswa okuyimfuneko kwintetho yayo iqala.I-receptor ye-GF-GF isebenze ukubonakaliswa kwe-Akt kunye ne-ERK yokubonisa.Ukusetyenziswa kwe-Akt kuya kuthintela iindlela ze-2 nge-phosphorylation: (1) i-glycogen synthase kinase-3β ekhuthaza ukuthotywa kwe-β-catenin, kunye (2) ne-Bcl-2-ehambelana nomgqugquzeli wokufa, ojongene nokubangela i-apoptosis.Njengoko kuchazwe ngababhali, i-PRP inokunyusa i-vascularization,ukuthintela i-apoptosis, kunye nokwandisa ixesha lesigaba se-anagen.
Ixesha lokuposa: Aug-24-2022